[HTML][HTML] Genetic and biochemical properties of streptococcal NAD-glycohydrolase inhibitor
H Kimoto, Y Fujii, S Hirano, Y Yokota… - Journal of biological …, 2006 - ASBMB
The gene encoding streptolysin O (slo), a cytolysin of hemolytic streptococci, is transcribed
polycistronically from the promoter of the preceding NAD-glycohydrolase (NADase) gene
(nga). Between nga and slo, a putative open reading frame (orf1) is located whose function
has been totally unknown. Present investigation demonstrated that the orf1 encodes a
protein designated as streptococcal NADase inhibitor (SNI). From its nucleotide sequence,
SNI was inferred to comprise 161 amino acid residues and the deduced molecular weight …
polycistronically from the promoter of the preceding NAD-glycohydrolase (NADase) gene
(nga). Between nga and slo, a putative open reading frame (orf1) is located whose function
has been totally unknown. Present investigation demonstrated that the orf1 encodes a
protein designated as streptococcal NADase inhibitor (SNI). From its nucleotide sequence,
SNI was inferred to comprise 161 amino acid residues and the deduced molecular weight …