Pathways of antigen processing

JS Blum, PA Wearsch… - Annual review of …, 2013 - annualreviews.org
JS Blum, PA Wearsch, P Cresswell
Annual review of immunology, 2013annualreviews.org
T cell recognition of antigen-presenting cells depends on their expression of a spectrum of
peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II)
molecules. Conversion of antigens from pathogens or transformed cells into MHC-I-and
MHC-II-bound peptides is critical for mounting protective T cell responses, and similar
processing of self proteins is necessary to establish and maintain tolerance. Cells use a
variety of mechanisms to acquire protein antigens, from translation in the cytosol to …
T cell recognition of antigen-presenting cells depends on their expression of a spectrum of peptides bound to major histocompatibility complex class I (MHC-I) and class II (MHC-II) molecules. Conversion of antigens from pathogens or transformed cells into MHC-I- and MHC-II-bound peptides is critical for mounting protective T cell responses, and similar processing of self proteins is necessary to establish and maintain tolerance. Cells use a variety of mechanisms to acquire protein antigens, from translation in the cytosol to variations on the theme of endocytosis, and to degrade them once acquired. In this review, we highlight the aspects of MHC-I and MHC-II biosynthesis and assembly that have evolved to intersect these pathways and sample the peptides that are produced.
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