[HTML][HTML] Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression

M Grunewald, S Johnson, D Lu, Z Wang… - Journal of Biological …, 2012 - ASBMB
Chronic stress is a risk factor for psychiatric illnesses, including depressive disorders, and is
characterized by increased blood glucocorticoids and brain monoamine oxidase A (MAO A,
which degrades monoamine neurotransmitters). This study elucidates the relationship
between stress-induced MAO A and the transcription factor Kruppel-like factor 11 (KLF11,
also called TIEG2, a member of the Sp/KLF-family), which inhibits cell growth. We report that
1) a glucocorticoid (dexamethasone) increases KLF11 mRNA and protein levels in cultured …