Management of Wilson's disease with zinc sulphate: experience in a series of 27 patients

TU Hoogenraad, J Van Hattum… - Journal of the …, 1987 - Elsevier
Abstract Evaluation of the literature concerning the various approaches for the treatment of
Wilson's disease led to the conclusion that zinc sulphate might be a good choice because it
is effective and relatively safe. Twenty seven patients were managed with zinc sulphate for a
total period of 142 patients-years. The drug was administered in doses varying from 300 to
1200 mg/day. Of the 9 patients who were treated with zinc from the start, 8 improved and one
died from severe cirrhosis. All 8 patients who were placed on zinc after intolerance to …