[HTML][HTML] Interleukin-1β-mediated suppression of RXR: RAR transactivation of the Ntcp promoter is JNK-dependent
D Li, TL Zimmerman, S Thevananther, HY Lee… - Journal of Biological …, 2002 - ASBMB
Bile flow is rapidly and markedly reduced in hepatic inflammation, correlating with
suppression of critical hepatic bile acid transporter gene expression, including the principal
hepatic bile acid importer, the Na+/taurocholate co-transporting polypeptide (Ntcp, Slc10a1).
Endotoxin treatment of rats and interleukin-1β (IL-1β) treatment of liver-derived HepG2 cells
leads to a marked decline in the nuclear binding activity of a main Ntcp gene regulator, the
nuclear receptor heterodimer retinoid X receptor: retinoic acid receptor (RXR: RAR). How IL …
suppression of critical hepatic bile acid transporter gene expression, including the principal
hepatic bile acid importer, the Na+/taurocholate co-transporting polypeptide (Ntcp, Slc10a1).
Endotoxin treatment of rats and interleukin-1β (IL-1β) treatment of liver-derived HepG2 cells
leads to a marked decline in the nuclear binding activity of a main Ntcp gene regulator, the
nuclear receptor heterodimer retinoid X receptor: retinoic acid receptor (RXR: RAR). How IL …