The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of
several conjugated compounds across the apical membrane of the hepatocyte into the bile
canaliculi. We identified MRP2 in a screen designed to isolate genes that are regulated by
the farnesoid X-activated receptor (FXR, NR1H4). MRP2 mRNA levels were induced
following treatment of human or rat hepatocytes with either naturally occurring
(chenodeoxycholic acid) or synthetic (GW4064) FXR ligands. In addition, we have shown …