Effect of tumor-derived cytokines and growth factors on differentiation and immune suppressive features of myeloid cells in cancer
S Kusmartsev, DI Gabrilovich - Cancer and Metastasis Reviews, 2006 - Springer
Cancer and Metastasis Reviews, 2006•Springer
It is well established that cancers affect differentiation of dendritic cells and promote systemic
expansion of immune suppressive immature myeloid cells. This phenomenon may represent
a mechanism of tumor escape from immune attack and could have significant impact on
tumor progression. In this review we discuss the role of different tumor-derived factors, which
were implicated in abnormal myeloid cell differentiation. The role of reactive oxygen species
as well as JAK/STAT signaling in mechanisms of the effects of tumor-derived factors on …
expansion of immune suppressive immature myeloid cells. This phenomenon may represent
a mechanism of tumor escape from immune attack and could have significant impact on
tumor progression. In this review we discuss the role of different tumor-derived factors, which
were implicated in abnormal myeloid cell differentiation. The role of reactive oxygen species
as well as JAK/STAT signaling in mechanisms of the effects of tumor-derived factors on …
Abstract
It is well established that cancers affect differentiation of dendritic cells and promote systemic expansion of immune suppressive immature myeloid cells. This phenomenon may represent a mechanism of tumor escape from immune attack and could have significant impact on tumor progression. In this review we discuss the role of different tumor-derived factors, which were implicated in abnormal myeloid cell differentiation. The role of reactive oxygen species as well as JAK/STAT signaling in mechanisms of the effects of tumor-derived factors on myeloid cells is also discussed.
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