High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate–activated protein kinase

M Adachi, DA Brenner - Hepatology, 2008 - journals.lww.com
Adiponectin is an adipocyte-derived, antidiabetic, antiatherogenic adipocytokine that is
present in serum as 3 isoforms. Decreased plasma adiponectin levels are closely
associated with the severity of nonalcoholic fatty liver diseases. This study was designed to
elucidate a role of adiponectin and its mediator adenosine monophosphate–activated
protein kinase (AMPK) on proliferation of activated hepatic stellate cells (HSCs), the key
cells promoting fibrosis. Immortalized human HSC line hTERT and primary rat HSCs were …