Vitamin E and nonalcoholic fatty liver disease
T Pacana, AJ Sanyal - Current Opinion in Clinical Nutrition & …, 2012 - journals.lww.com
T Pacana, AJ Sanyal
Current Opinion in Clinical Nutrition & Metabolic Care, 2012•journals.lww.comThe prevalence of NAFLD is likely to increase over time due to the epidemics of obesity and
diabetes. Presently, there is no definitive treatment for NAFLD. Based on available evidence,
vitamin E (RRR-α-tocopherol) is only recommended in NASH adults without diabetes or
cirrhosis and with aggressive histology. Validation is needed in children before its use can
be recommended. Longer follow-up of randomized controlled trials are needed to assess
long-term vitamin E safety.
diabetes. Presently, there is no definitive treatment for NAFLD. Based on available evidence,
vitamin E (RRR-α-tocopherol) is only recommended in NASH adults without diabetes or
cirrhosis and with aggressive histology. Validation is needed in children before its use can
be recommended. Longer follow-up of randomized controlled trials are needed to assess
long-term vitamin E safety.
Summary
The prevalence of NAFLD is likely to increase over time due to the epidemics of obesity and diabetes. Presently, there is no definitive treatment for NAFLD. Based on available evidence, vitamin E (RRR-α-tocopherol) is only recommended in NASH adults without diabetes or cirrhosis and with aggressive histology. Validation is needed in children before its use can be recommended. Longer follow-up of randomized controlled trials are needed to assess long-term vitamin E safety.
Lippincott Williams & Wilkins