Role of insulin resistance and lipotoxicity in non-alcoholic steatohepatitis
K Cusi - Clinics in liver disease, 2009 - liver.theclinics.com
At first glance, obesity, the metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM),
cardiovascular disease (CVD), and non-alcoholic fatty liver disease (NAFLD) and non-
alcoholic steatohepatitis (NASH) appear to be very different and separate entities. However,
they are closely linked by a common underlying metabolic abnormality: adipose tissue
insulin resistance leading to multiorgan ''lipotoxicity.''Although the degree of compromise of
each end-organ varies from patient to patient and the causes remain poorly understood …
cardiovascular disease (CVD), and non-alcoholic fatty liver disease (NAFLD) and non-
alcoholic steatohepatitis (NASH) appear to be very different and separate entities. However,
they are closely linked by a common underlying metabolic abnormality: adipose tissue
insulin resistance leading to multiorgan ''lipotoxicity.''Although the degree of compromise of
each end-organ varies from patient to patient and the causes remain poorly understood …