SB-431542 is a potent and specific inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors ALK4, ALK5, and ALK7
GJ Inman, FJ Nicolás, JF Callahan, JD Harling… - Molecular …, 2002 - Elsevier
Small molecule inhibitors have proven extremely useful for investigating signal transduction
pathways and have the potential for development into therapeutics for inhibiting signal
transduction pathways whose activities contribute to human diseases. Transforming growth
factor β (TGF-β) is a member of a large family of pleiotropic cytokines that are involved in
many biological processes, including growth control, differentiation, migration, cell survival,
adhesion, and specification of developmental fate, in both normal and diseased states. TGF …
pathways and have the potential for development into therapeutics for inhibiting signal
transduction pathways whose activities contribute to human diseases. Transforming growth
factor β (TGF-β) is a member of a large family of pleiotropic cytokines that are involved in
many biological processes, including growth control, differentiation, migration, cell survival,
adhesion, and specification of developmental fate, in both normal and diseased states. TGF …