Overactivation of ionotropic glutamate receptors induces a Ca2+ overload into the cytoplasm
that leads neurons to excitotoxic death, a process that has been linked to several
neurodegenerative disorders. While the role of mitochondria and its involvement in
excitotoxicity have been widely studied, the contribution of endoplasmic reticulum (ER),
another crucial intracellular store in maintaining Ca2+ homeostasis, is not fully understood.
In this study, we analyzed the contribution of ER-Ca2+ release through ryanodine (RyR) and …