Inositol 1, 4, 5-trisphosphate receptors as signal integrators
RL Patterson, D Boehning… - Annual review of …, 2004 - annualreviews.org
▪ Abstract The inositol 1, 4, 5 trisphosphate (IP3) receptor (IP3R) is a Ca2+ release channel
that responds to the second messenger IP3. Exquisite modulation of intracellular Ca2+
release via IP3Rs is achieved by the ability of IP3R to integrate signals from numerous small
molecules and proteins including nucleotides, kinases, and phosphatases, as well as
nonenzyme proteins. Because the ion conduction pore composes only∼ 5% of the IP3R, the
great bulk of this large protein contains recognition sites for these substances. Through …
that responds to the second messenger IP3. Exquisite modulation of intracellular Ca2+
release via IP3Rs is achieved by the ability of IP3R to integrate signals from numerous small
molecules and proteins including nucleotides, kinases, and phosphatases, as well as
nonenzyme proteins. Because the ion conduction pore composes only∼ 5% of the IP3R, the
great bulk of this large protein contains recognition sites for these substances. Through …
