[HTML][HTML] Lecithin: retinol acyltransferase is responsible for amidation of retinylamine, a potent inhibitor of the retinoid cycle

M Golczak, Y Imanishi, V Kuksa, T Maeda… - Journal of Biological …, 2005 - ASBMB
Lecithin: retinol acyltransferase (LRAT) catalyzes the transfer of an acyl group from the sn-1
position of phosphatidylcholine to all-trans-retinol (vitamin A) and plays an essential role in
the regeneration of visual chromophore as well as in the metabolism of vitamin A. Here we
demonstrate that retinylamine (Ret-NH 2), a potent and selective inhibitor of 11-cis-retinal
biosynthesis (Golczak, M., Kuksa, V., Maeda, T., Moise, AR, and Palczewski, K.(2005) Proc.
Natl. Acad. Sci. USA 102, 8162-8167), is a substrate for LRAT. LRAT catalyzes the transfer …