[HTML][HTML] Heme oxygenase-1 promotes survival of renal cancer cells through modulation of apoptosis-and autophagy-regulating molecules
P Banerjee, A Basu, B Wegiel, LE Otterbein… - Journal of Biological …, 2012 - ASBMB
The cytoprotective enzyme heme oxygenase-1 (HO-1) is often overexpressed in different
types of cancers and promotes cancer progression. We have recently shown that the Ras-
Raf-ERK pathway induces HO-1 to promote survival of renal cancer cells. Here, we
examined the possible mechanisms underlying HO-1-mediated cell survival. Considering
the growing evidence about the significance of apoptosis and autophagy in cancer, we tried
to investigate how HO-1 controls these events to regulate survival of cancer cells …
types of cancers and promotes cancer progression. We have recently shown that the Ras-
Raf-ERK pathway induces HO-1 to promote survival of renal cancer cells. Here, we
examined the possible mechanisms underlying HO-1-mediated cell survival. Considering
the growing evidence about the significance of apoptosis and autophagy in cancer, we tried
to investigate how HO-1 controls these events to regulate survival of cancer cells …