Decreased plasma levels of IL-33 could contribute to the altered function of Th2 lymphocytes in patients with polycythemia vera and essential thrombocythemia
Cancer investigation, 2013•Taylor & Francis
Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative
neoplasms (MPNs) primarily characterized by erythrocytosis and thrombocytosis,
respectively (1). In addition, quality of life is adversely affected by a spectrum of disease
complications including pruritus. Interleukin-33 (IL-33) is a cytokine from the IL-1 family,
which has been linked to important diseases, including asthma, rheumatoid arthritis,
ulcerative colitis, metabolic, neurologic, and cardiovascular diseases. IL-33 drives cytokine …
neoplasms (MPNs) primarily characterized by erythrocytosis and thrombocytosis,
respectively (1). In addition, quality of life is adversely affected by a spectrum of disease
complications including pruritus. Interleukin-33 (IL-33) is a cytokine from the IL-1 family,
which has been linked to important diseases, including asthma, rheumatoid arthritis,
ulcerative colitis, metabolic, neurologic, and cardiovascular diseases. IL-33 drives cytokine …
Polycythemia vera (PV) and essential thrombocythemia (ET) are myeloproliferative neoplasms (MPNs) primarily characterized by erythrocytosis and thrombocytosis, respectively (1). In addition, quality of life is adversely affected by a spectrum of disease complications including pruritus. Interleukin-33 (IL-33) is a cytokine from the IL-1 family, which has been linked to important diseases, including asthma, rheumatoid arthritis, ulcerative colitis, metabolic, neurologic, and cardiovascular diseases. IL-33 drives cytokine production in type 2 innate lymphoid cells (ILCs), T-helper (Th) 2 lymphocytes, mast cells, basophils, eosinophils, invariant natural killer T (iNKT), and natural killer (NK) cells (2).
Taylor & Francis Online