miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis

V Fulci, G Scappucci, GD Sebastiani, C Giannitti… - Human immunology, 2010 - Elsevier
miRNAs have recently emerged as key regulators of the immune system, being involved in
lymphocyte selection and proliferation, in Treg cells differentiation, and in hematopoiesis in
general. Rheumatoid arthritis (RA) is an autoimmune pathology the etiology of which is still
obscure. Although a multifactorial pathogenesis has been hypothesized, the precise
mechanisms leading to the disease are still poorly understood at the molecular level. miRNA
expression profile analysis highlighted that miR-223 is the only miRNA that is strikingly …