Toward a unified theory of renal progression

RC Harris, EG Neilson - Annu. Rev. Med., 2006 - annualreviews.org
Various disciplines within nephrology investigate the mechanisms by which kidneys fail.
Progress in the areas of glomerular hemodynamics, proteinuria, tubular biology, interstitial
nephritis, fibroblast formation, and fibrosis have added kernels of information that together
support a unified theory of renal progression. Prevention of progression to end-stage
disease has largely focused on control of systemic and glomerular hypertension. Current
success in delaying a decline in glomerular filtration rate underlines the promise of a more …