Therapy of type 1 diabetes with CD4+ CD25highCD127-regulatory T cells prolongs survival of pancreatic islets—Results of one year follow-up
N Marek-Trzonkowska, M Myśliwiec, A Dobyszuk… - Clinical …, 2014 - Elsevier
It is hypothesized that CD4+ CD25+ FoxP3+ regulatory T cells (Tregs) can prevent
destruction of pancreatic islets protecting from type 1 diabetes (DM1). Here we present
results of one year follow-up of 12 DM1 children treated with autologous expanded ex vivo
Tregs. Patients received either a single or double Tregs infusion up to the total dose of 30×
10 6/kg. No severe adverse effects were observed. The treatment did not impair post-
immunization antibody responses. Tregs infusion was followed by increase in Tregs number …
destruction of pancreatic islets protecting from type 1 diabetes (DM1). Here we present
results of one year follow-up of 12 DM1 children treated with autologous expanded ex vivo
Tregs. Patients received either a single or double Tregs infusion up to the total dose of 30×
10 6/kg. No severe adverse effects were observed. The treatment did not impair post-
immunization antibody responses. Tregs infusion was followed by increase in Tregs number …