Identification of a novel subset of human circulating memory CD4+ T cells that produce both IL-17A and IL-4
L Cosmi, L Maggi, V Santarlasci, M Capone… - Journal of Allergy and …, 2010 - Elsevier
BACKGROUND: IL-17A has been suggested to play a pathogenic role in bronchial asthma
and other allergic disorders. OBJECTIVE: Study of the relationship between human IL-17A–
producing CD4+ TH cells (TH17) and IL-4–producing CD4+ TH (TH2) cells. METHODS: T-
cell clones generated from the CCR6+ CD161+ fraction of human circulating CD4+ T cells,
which contains virtually all TH17 cells, as well as circulating CD4+ T cells from both healthy
subjects and patients with asthma, were assessed by flow cytometry for their cytokine …
and other allergic disorders. OBJECTIVE: Study of the relationship between human IL-17A–
producing CD4+ TH cells (TH17) and IL-4–producing CD4+ TH (TH2) cells. METHODS: T-
cell clones generated from the CCR6+ CD161+ fraction of human circulating CD4+ T cells,
which contains virtually all TH17 cells, as well as circulating CD4+ T cells from both healthy
subjects and patients with asthma, were assessed by flow cytometry for their cytokine …