The biology of hematopoietic stem cells
SJ Morrison, N Uchida… - Annual review of cell and …, 1995 - annualreviews.org
SJ Morrison, N Uchida, IL Weissman
Annual review of cell and developmental biology, 1995•annualreviews.org36 MORRISON, UCHIDA & WEISSMAN more HSC. In mouse and human, HSC represent up
to 0.05% of cells in the bone marrow. HSC are almost entirely responsible for the
radioprotective and short-and long-term reconstituting effects observed after bone marrow
trans plantation. The subsets of HSC that give rise to short-term vs long-term multilineage
reconstitution can be separated by phenotype, demonstrating that the fates of HSC are
intrinsically determined. Here we review the ontogeny and biology of HSC, their expression …
to 0.05% of cells in the bone marrow. HSC are almost entirely responsible for the
radioprotective and short-and long-term reconstituting effects observed after bone marrow
trans plantation. The subsets of HSC that give rise to short-term vs long-term multilineage
reconstitution can be separated by phenotype, demonstrating that the fates of HSC are
intrinsically determined. Here we review the ontogeny and biology of HSC, their expression …
36 MORRISON, UCHIDA & WEISSMAN more HSC. In mouse and human, HSC represent up to 0.05% of cells in the bone marrow. HSC are almost entirely responsible for the radioprotective and short-and long-term reconstituting effects observed after bone marrow trans plantation. The subsets of HSC that give rise to short-term vs long-term multilineage reconstitution can be separated by phenotype, demonstrating that the fates of HSC are intrinsically determined. Here we review the ontogeny and biology of HSC, their expression of fate-determining genes, and the clinical importance of HSC for transplantation and gene therapy,
Annual Reviews