The expanding roles of Gβγ subunits in G protein–coupled receptor signaling and drug action
SM Khan, R Sleno, S Gora, P Zylbergold… - Pharmacological …, 2013 - Elsevier
Gβγ subunits from heterotrimeric G proteins perform a vast array of functions in cells with
respect to signaling, often independently as well as in concert with Gα subunits. However,
the eponymous term “Gβγ” does not do justice to the fact that 5 Gβ and 12 Gγ isoforms have
evolved in mammals to serve much broader roles beyond their canonical roles in cellular
signaling. We explore the phylogenetic diversity of Gβγ subunits with a view toward
understanding these expanded roles in different cellular organelles. We suggest that the …
respect to signaling, often independently as well as in concert with Gα subunits. However,
the eponymous term “Gβγ” does not do justice to the fact that 5 Gβ and 12 Gγ isoforms have
evolved in mammals to serve much broader roles beyond their canonical roles in cellular
signaling. We explore the phylogenetic diversity of Gβγ subunits with a view toward
understanding these expanded roles in different cellular organelles. We suggest that the …
