Type I interferons (α/β) in immunity and autoimmunity
AN Theofilopoulos, R Baccala, B Beutler… - Annu. Rev …, 2005 - annualreviews.org
▪ Abstract The significance of type I interferons (IFN-α/β) in biology and medicine renders
research on their activities continuously relevant to our understanding of normal and
abnormal (auto) immune responses. This relevance is bolstered by discoveries that
unambiguously establish IFN-α/β, among the multitude of cytokines, as dominant in defining
qualitative and quantitative characteristics of innate and adaptive immune processes.
Recent advances elucidating the biology of these key cytokines include better definition of …
research on their activities continuously relevant to our understanding of normal and
abnormal (auto) immune responses. This relevance is bolstered by discoveries that
unambiguously establish IFN-α/β, among the multitude of cytokines, as dominant in defining
qualitative and quantitative characteristics of innate and adaptive immune processes.
Recent advances elucidating the biology of these key cytokines include better definition of …
