Secretion of soluble chemotactic factors, including interleukin-6: a mechanism for the recruitment of CD8-positive T lymphocytes to human liver allografts during …

M Hathaway, D Burnett, E Elias, DH Adams - Hepatology, 1993 - journals.lww.com
In 35 patients receiving first liver transplants we assessed the chemotactic responsiveness
of peripheral blood lymphocytes to bile, the subset composition of the responding population
and the ability of peripheral blood lymphocytes to produce chemotactic factors. In 13 patients
in whom acute rejection developed, lymphocyte chemotaxis in vitro was significantly greater
in bile sampled 1 or 2 days after transplantation and before episodes of acute rejection than
in bile sampled when rejection was clinically apparent or after steroid therapy during stable …