Recent studies on the effect of aging in epidermal cells have evidenced a decrease of
proteasome activity and content, suggesting that proteasome is down-regulated in aged
cells. The 20S proteasome is the major proteolytic system that has been implicated in
removal of abnormal and oxidatively damaged proteins. Therefore, a decreased proteasome
content may explain, at least in part, the well-documented age-related accumulation of
oxidized proteins. To gain further insight in other mechanisms that may be implicated in a …