Group 2 innate lymphoid cells in lung inflammation
BWS Li, RW Hendriks - Immunology, 2013 - Wiley Online Library
BWS Li, RW Hendriks
Immunology, 2013•Wiley Online LibraryAlthough allergic asthma is a heterogeneous disease, allergen‐specific T helper 2 (T h2)
cells producing the key cytokines involved in type 2 inflammation, interleukin‐4 (IL‐4), IL‐5
and IL‐13, are thought to play a major role in asthma pathogenesis. This model is
challenged by the recent discovery of group 2 innate lymphoid cells (ILC 2) that represent a
critical innate source of type 2 cytokines. These ILC 2 are activated by epithelial cell‐derived
cytokines, including IL‐25 and IL‐33, which have been implicated in the initiation of asthma …
cells producing the key cytokines involved in type 2 inflammation, interleukin‐4 (IL‐4), IL‐5
and IL‐13, are thought to play a major role in asthma pathogenesis. This model is
challenged by the recent discovery of group 2 innate lymphoid cells (ILC 2) that represent a
critical innate source of type 2 cytokines. These ILC 2 are activated by epithelial cell‐derived
cytokines, including IL‐25 and IL‐33, which have been implicated in the initiation of asthma …
Summary
Although allergic asthma is a heterogeneous disease, allergen‐specific T helper 2 (Th2) cells producing the key cytokines involved in type 2 inflammation, interleukin‐4 (IL‐4), IL‐5 and IL‐13, are thought to play a major role in asthma pathogenesis. This model is challenged by the recent discovery of group 2 innate lymphoid cells (ILC2) that represent a critical innate source of type 2 cytokines. These ILC2 are activated by epithelial cell‐derived cytokines, including IL‐25 and IL‐33, which have been implicated in the initiation of asthma. In this review, we will discuss recent studies supporting a significant role for ILC2 in lung inflammation, with special attention to allergen‐induced asthma.
Wiley Online Library