Quantitation of cell number by a positron emission tomography reporter gene strategy
H Su, A Forbes, SS Gambhir, J Braun - Molecular Imaging & Biology, 2004 - Elsevier
PURPOSE: An important potential of positron emission tomography (PET) is the capacity for
quantitation of cell signals in an anatomic regions of interest. However, little is known about
the constraints and parameters for using PET signal detection to establish cell numbers in
regions of interest. In this study, we determined the correlation of PET signal to cell number,
and characterized the cellular limit of detection for PET imaging. PROCEDURES: Cells
expressing the herpes simplex virus type I thymidine kinase PET reporter gene (HSV1 …
quantitation of cell signals in an anatomic regions of interest. However, little is known about
the constraints and parameters for using PET signal detection to establish cell numbers in
regions of interest. In this study, we determined the correlation of PET signal to cell number,
and characterized the cellular limit of detection for PET imaging. PROCEDURES: Cells
expressing the herpes simplex virus type I thymidine kinase PET reporter gene (HSV1 …