Vaccines and melanoma

PA Ott, EF Fritsch, CJ Wu… - Hematology/Oncology …, 2014 - hemonc.theclinics.com
Vaccination against melanoma represents an effort to stimulate an antitumor immune
response that is directed either against an established tumor in patients with unresectable
metastatic disease, or against micrometastatic disease in patients who are at high risk for
recurrence after surgical resection. In both situations, the host has already failed the task of
cancer immunosurveillance. The reasons for this failure are either the complete lack of an
antimelanoma immune response or tumor-mediated immune evasion, caused by numerous …