Dysfunctional adiposity and the risk of prediabetes and type 2 diabetes in obese adults

IJ Neeland, AT Turer, CR Ayers, TM Powell-Wiley… - Jama, 2012 - jamanetwork.com
Context The risk of type 2 diabetes mellitus is heterogeneous among obese individuals.
Factors that discriminate prediabetes or diabetes risk within this population have not been
well characterized. A dysfunctional adiposity phenotype, characterized by excess visceral fat
and insulin resistance, may contribute to diabetes development in those with obesity.
Objective To investigate associations between adiposity phenotypes and risk for incident
prediabetes and diabetes in a multiethnic, population-based cohort of obese adults. Design …