Protective effects of catalase on retinal ischemia/reperfusion injury in rats

B Chen, L Tang - Experimental eye research, 2011 - Elsevier
Retinal ischemia/reperfusion (I/R) injury causes profound tissue damage, especially retinal
ganglion cell (RGC) death. The aims of the study were to investigate whether catalase (CAT)
has a neuroprotective effect on RGC after I/R injury in rats, and to determine the possible
antioxidant mechanism. Wistar female rats were randonmized into four groups: normal
control group (Control group), retinal I/R with vehicle group (I/R with vehicle group), retinal
I/R with AAV-CAT group (I/R with AAV-CAT group), and normal retina with AAV-CAT group …