Phosphate groups as substrate determinants for casein kinase I action.
H Flotow, PR Graves, AQ Wang, CJ Fiol… - Journal of Biological …, 1990 - ASBMB
Phosphorylation of rabbit muscle glycogen synthase by cyclic AMP-dependent protein
kinase has been shown to enhance subsequent phosphorylation by casein kinase I (Flotow,
H., and Roach, PJ (1989) J. Biol. Chem. 264, 9126-9128). In the present study, synthetic
peptides based on the sequences of the four phosphorylated regions in muscle glycogen
synthase were used to probe the role of substrate phosphorylation in casein kinase I action.
With all four peptides, prior phosphorylation significantly stimulated phosphorylation by …
kinase has been shown to enhance subsequent phosphorylation by casein kinase I (Flotow,
H., and Roach, PJ (1989) J. Biol. Chem. 264, 9126-9128). In the present study, synthetic
peptides based on the sequences of the four phosphorylated regions in muscle glycogen
synthase were used to probe the role of substrate phosphorylation in casein kinase I action.
With all four peptides, prior phosphorylation significantly stimulated phosphorylation by …