[HTML][HTML] CK1α plays a central role in mediating MDM2 control of p53 and E2F-1 protein stability
The ubiquitin ligase murine double minute clone 2 (MDM2) mediates ubiquitination and
degradation of the tumor suppressor p53. The activation and stabilization of p53 by contrast
is maintained by enzymes catalyzing p53 phosphorylation and acetylation. Casein kinase 1
(CK1) is one such enzyme; it stimulates p53 after transforming growth factor-β treatment,
irradiation, or DNA virus infection. We analyzed whether CK1 regulates p53 protein stability
in unstressed conditions. Depletion of CK1 using small interfering RNA or inhibition of CK1 …
degradation of the tumor suppressor p53. The activation and stabilization of p53 by contrast
is maintained by enzymes catalyzing p53 phosphorylation and acetylation. Casein kinase 1
(CK1) is one such enzyme; it stimulates p53 after transforming growth factor-β treatment,
irradiation, or DNA virus infection. We analyzed whether CK1 regulates p53 protein stability
in unstressed conditions. Depletion of CK1 using small interfering RNA or inhibition of CK1 …