Regulation of hepatocyte nuclear factor 4α-mediated transcription
FJ Gonzalez - Drug metabolism and pharmacokinetics, 2008 - Elsevier
Hepatocyte nuclear factor 4α (HNF4α, NR2A1) is required for development of the liver and
for controlling the expression of many genes specifically expressed in the liver and
associated with a number of critical metabolic pathways. Among the genes regulated by
HNF4α are the xenobiotic-metabolizing cytochromes P450, UDP-glucuronosyltransferases
and sulfotransferases thus making this transcription factor critical in the control of drug
metabolism. HNF4α, a member of the nuclear receptor superfamily, binds as a homodimer to …
for controlling the expression of many genes specifically expressed in the liver and
associated with a number of critical metabolic pathways. Among the genes regulated by
HNF4α are the xenobiotic-metabolizing cytochromes P450, UDP-glucuronosyltransferases
and sulfotransferases thus making this transcription factor critical in the control of drug
metabolism. HNF4α, a member of the nuclear receptor superfamily, binds as a homodimer to …