In situ detection of oxidative DNA damage, 8-hydroxydeoxyguanosine, in chronic human liver disease
T Kitada, S Seki, S Iwai, T Yamada, H Sakaguchi… - Journal of …, 2001 - Elsevier
Background/Aims: 8-Hydroxydeoxyguanosine (8-OHdG) is a promutagenic DNA lesion
produced by oxygen radicals and is recognized as a useful marker in estimating DNA
damage induced by oxidative stress. Methods: Hepatic expression of 8-OHdG was
immunohistochemically investigated in control and diseased human livers. Results: While
no positive immunolabeling for 8-OHdG was observed in control livers, 8-OHdG was widely
evident in diseased livers. Nuclear expression of 8-OHdG in the hepatocytes and bile duct …
produced by oxygen radicals and is recognized as a useful marker in estimating DNA
damage induced by oxidative stress. Methods: Hepatic expression of 8-OHdG was
immunohistochemically investigated in control and diseased human livers. Results: While
no positive immunolabeling for 8-OHdG was observed in control livers, 8-OHdG was widely
evident in diseased livers. Nuclear expression of 8-OHdG in the hepatocytes and bile duct …