[HTML][HTML] A proposed mechanism for the promotion of prion conversion involving a strictly conserved tyrosine residue in the β2-α2 loop of PrPC

TD Kurt, L Jiang, C Bett, D Eisenberg… - Journal of Biological …, 2014 - ASBMB
The transmission of infectious prions into different host species requires compatible prion
protein (PrP) primary structures, and even one heterologous residue at a pivotal position can
block prion infection. Mapping the key amino acid positions that govern cross-species prion
conversion has not yet been possible, although certain residue positions have been
identified as restrictive, including residues in the β 2-α 2 loop region of PrP. To further define
how β 2-α 2 residues impact conversion, we investigated residue substitutions in PrP C …