Congenital sideroblastic anemias: iron and heme lost in mitochondrial translation

MD Fleming - Hematology 2010, the American Society of …, 2011 - ashpublications.org
Hematology 2010, the American Society of Hematology Education …, 2011ashpublications.org
The congenital sideroblastic anemias (CSAs) are an uncommon, diverse class of inherited
hematopoietic disorders characterized by pathological deposition of iron in the mitochondria
of erythroid precursors. In recent years, the genetic causes of several clinically distinctive
forms of CSA have been elucidated, which has revealed common themes in their
pathogenesis. In particular, most, if not all, can be attributed to disordered mitochondrial
heme synthesis, iron-sulfur cluster biogenesis, or pathways related to mitochondrial protein …
Abstract
The congenital sideroblastic anemias (CSAs) are an uncommon, diverse class of inherited hematopoietic disorders characterized by pathological deposition of iron in the mitochondria of erythroid precursors. In recent years, the genetic causes of several clinically distinctive forms of CSA have been elucidated, which has revealed common themes in their pathogenesis. In particular, most, if not all, can be attributed to disordered mitochondrial heme synthesis, iron-sulfur cluster biogenesis, or pathways related to mitochondrial protein synthesis. This review summarizes the clinical features, molecular genetics, and pathophysiology of each of the CSAs in the context of these pathways.
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