[HTML][HTML] Akt activation in platelets depends on Gi signaling pathways
S Kim, J Jin, SP Kunapuli - Journal of Biological Chemistry, 2004 - ASBMB
The serine-threonine kinase Akt has been established as an important signaling
intermediate in regulating cell survival, cell cycle progression, as well as agonist-induced
platelet activation. Stimulation of platelets with various agonists including thrombin results in
Akt activation. As thrombin can stimulate multiple G protein signaling pathways, we
investigated the mechanism of thrombin-induced activation of Akt. Stimulation of platelets
with a PAR1-activating peptide (SFLLRN), PAR4-activating peptide (AYPGKF), and thrombin …
intermediate in regulating cell survival, cell cycle progression, as well as agonist-induced
platelet activation. Stimulation of platelets with various agonists including thrombin results in
Akt activation. As thrombin can stimulate multiple G protein signaling pathways, we
investigated the mechanism of thrombin-induced activation of Akt. Stimulation of platelets
with a PAR1-activating peptide (SFLLRN), PAR4-activating peptide (AYPGKF), and thrombin …