The cell biology of neural stem and progenitor cells and its significance for their proliferation versus differentiation during mammalian brain development

LM Farkas, WB Huttner - Current opinion in cell biology, 2008 - Elsevier
LM Farkas, WB Huttner
Current opinion in cell biology, 2008Elsevier
The switch of neural stem and progenitor cells from proliferation to differentiation during
development is a crucial determinant of brain size. This switch is intimately linked to the
architecture of the two principal classes of neural stem and progenitor cells, the apical
(neuroepithelial, radial glial) and basal (intermediate) progenitors, which in turn is crucial for
their symmetric versus asymmetric divisions. Focusing on the developing rodent neocortex,
we discuss here recent advances in understanding the cell biology of apical and basal …
The switch of neural stem and progenitor cells from proliferation to differentiation during development is a crucial determinant of brain size. This switch is intimately linked to the architecture of the two principal classes of neural stem and progenitor cells, the apical (neuroepithelial, radial glial) and basal (intermediate) progenitors, which in turn is crucial for their symmetric versus asymmetric divisions. Focusing on the developing rodent neocortex, we discuss here recent advances in understanding the cell biology of apical and basal progenitors, place key regulatory molecules into subcellular context, and highlight their roles in the control of proliferation versus differentiation.
Elsevier