Requirement for Liml in head-organizer function
W Shawlot, RR Behringer - Nature, 1995 - nature.com
W Shawlot, RR Behringer
Nature, 1995•nature.comLiml is a homeobox gene expressed in the organizer region of mouse embryos. To
investigate the role of Liml during embryogenesis, a targeted deletion of the Liml gene was
generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior
head structures but the remaining body axis developed normally. A partial secondary axis
developed anteriorly in some mutant embryos. Liml is thus an essential regulator of the
vertebrate head organizer.
investigate the role of Liml during embryogenesis, a targeted deletion of the Liml gene was
generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior
head structures but the remaining body axis developed normally. A partial secondary axis
developed anteriorly in some mutant embryos. Liml is thus an essential regulator of the
vertebrate head organizer.
Abstract
Liml is a homeobox gene expressed in the organizer region of mouse embryos. To investigate the role of Liml during embryogenesis, a targeted deletion of the Liml gene was generated in embryonic stem cells. Embryos homozygous for the null allele lacked anterior head structures but the remaining body axis developed normally. A partial secondary axis developed anteriorly in some mutant embryos. Liml is thus an essential regulator of the vertebrate head organizer.
nature.com