Preference for corn oil in olfactory-blocked mice in the conditioned place preference test and the two-bottle choice test

M Takeda, S Sawano, M Imaizumi, T Fushiki - Life sciences, 2001 - Elsevier
M Takeda, S Sawano, M Imaizumi, T Fushiki
Life sciences, 2001Elsevier
We studied the effects of olfactory stimuli on preference for corn oil in mice. In the
conditioned place preference test, voluntary intake of 100% corn oil by both olfactory normal
and ZnSO4-induced olfactory-blocked (anosmic) mice resulted in their place preference for
the corn oil-related box. In the olfactory normal mice, place preference was also observed by
voluntary intake of linoleic acid as well as of corn oil. In the two-bottle choice test, normal
mice showed significant preference for test fluids that contained corn oil at all concentrations …
We studied the effects of olfactory stimuli on preference for corn oil in mice. In the conditioned place preference test, voluntary intake of 100% corn oil by both olfactory normal and ZnSO4-induced olfactory-blocked (anosmic) mice resulted in their place preference for the corn oil-related box. In the olfactory normal mice, place preference was also observed by voluntary intake of linoleic acid as well as of corn oil. In the two-bottle choice test, normal mice showed significant preference for test fluids that contained corn oil at all concentrations (1 – 10%) tested relative to vehicle alone. However, the lower concentrations (1 and 3%) of corn oil were not preferred in the anosmic mice. These results suggested that stimuli other than olfaction contributed to the rewarding effects of corn oil, but at lower concentrations olfactory stimuli might act as a signal for the oil.
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