[HTML][HTML] Oleoylethanolamide stimulates lipolysis by activating the nuclear receptor peroxisome proliferator-activated receptor α (PPAR-α)

M Guzmán, JL Verme, J Fu, F Oveisi… - Journal of biological …, 2004 - ASBMB
Amides of fatty acids with ethanolamine (FAE) are biologically active lipids that participate in
a variety of biological functions, including the regulation of feeding. The polyunsaturated
FAE anandamide (arachidonoylethanolamide) increases food intake by activating G protein-
coupled cannabinoid receptors. On the other hand, the monounsaturated FAE
oleoylethanolamide (OEA) reduces feeding and body weight gain by activating the nuclear
receptor PPAR-α (peroxisome proliferator-activated receptor α). In the present report, we …