[HTML][HTML] G protein-coupled receptors in the hypothalamic paraventricular and supraoptic nuclei–serpentine gateways to neuroendocrine homeostasis

GGJ Hazell, CC Hindmarch, GR Pope, JA Roper… - Frontiers in …, 2012 - Elsevier
G protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors in
the mammalian genome. They are activated by a multitude of different ligands that elicit
rapid intracellular responses to regulate cell function. Unsurprisingly, a large proportion of
therapeutic agents target these receptors. The paraventricular nucleus (PVN) and supraoptic
nucleus (SON) of the hypothalamus are important mediators in homeostatic control. Many
modulators of PVN/SON activity, including neurotransmitters and hormones act via GPCRs …