[HTML][HTML] Food intake regulates oleoylethanolamide formation and degradation in the proximal small intestine

J Fu, G Astarita, S Gaetani, J Kim, BF Cravatt… - Journal of Biological …, 2007 - ASBMB
Oleoylethanolamide (OEA) is a lipid mediator that inhibits food intake by activating the
nuclear receptor peroxisome proliferator-activated receptor-α. In the rodent small intestine
OEA levels decrease during food deprivation and increase upon refeeding, suggesting that
endogenous OEA may participate in the regulation of satiety. Here we show that feeding
stimulates OEA mobilization in the mucosal layer of rat duodenum and jejunum but not in the
serosal layer from the same intestinal segments in other sections of the gastrointestinal tract …