[PDF][PDF] T cell acute lymphoblastic leukemia: NOTCHing the way toward a better treatment outcome
CH Pui - Cancer cell, 2009 - cell.com
CH Pui
Cancer cell, 2009•cell.comγ-secretase inhibitors block the activation of NOTCH1 but have limited activity against T cell
acute lymphoblastic leukemia (T-ALL) and cause severe gastrointestinal toxicity. In a recent
study, Real et al. show that a potent γ-secretase inhibitor potentiates the cytotoxicity of
dexamethasone against glucocorticoid-resistant T-ALL cells, while dexamethasone
abrogates the gastrointestinal toxicity induced by the γ-secretase inhibitor.
acute lymphoblastic leukemia (T-ALL) and cause severe gastrointestinal toxicity. In a recent
study, Real et al. show that a potent γ-secretase inhibitor potentiates the cytotoxicity of
dexamethasone against glucocorticoid-resistant T-ALL cells, while dexamethasone
abrogates the gastrointestinal toxicity induced by the γ-secretase inhibitor.
γ-secretase inhibitors block the activation of NOTCH1 but have limited activity against T cell acute lymphoblastic leukemia (T-ALL) and cause severe gastrointestinal toxicity. In a recent study, Real et al. show that a potent γ-secretase inhibitor potentiates the cytotoxicity of dexamethasone against glucocorticoid-resistant T-ALL cells, while dexamethasone abrogates the gastrointestinal toxicity induced by the γ-secretase inhibitor.
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