[PDF][PDF] Increased survival of CFTR knockout mice with an oral osmotic laxative
LL Clarke, LR Gawenis, CL Franklin… - Laboratory animal …, 1996 - researchgate.net
Abstract l Mouse models of cystic fibrosis that are generated by targeted disruption
(knockout) of the cystic fibrosis transmembrane conductance regulator gene, cftr (-/-),
typically die shortly after weaning, from intestinal obstruction/rupture caused by an inability
to secrete fluid into the bowel lumen. We investigated the use of a commercial osmotic
laxative, Colyteº, provided continuously in the drinking water, to increase the survival of cftr (-
/-) mice. Genotype analysis of 623 offspring surviving at 10 days of age yielded 28.1% cftr …
(knockout) of the cystic fibrosis transmembrane conductance regulator gene, cftr (-/-),
typically die shortly after weaning, from intestinal obstruction/rupture caused by an inability
to secrete fluid into the bowel lumen. We investigated the use of a commercial osmotic
laxative, Colyteº, provided continuously in the drinking water, to increase the survival of cftr (-
/-) mice. Genotype analysis of 623 offspring surviving at 10 days of age yielded 28.1% cftr …