Telomere biology in hematopoiesis and stem cell transplantation

SM Gadalla, SA Savage - Blood reviews, 2011 - Elsevier
Telomeres are long (TTAGGG) n nucleotide repeats and an associated protein complex
located at the end of the chromosomes. They shorten with every cell division and, thus are
markers for cellular aging, senescence, and replicative capacity. Telomere dysfunction is
linked to several bone marrow disorders, including dyskeratosis congenita, aplastic anemia,
myelodysplastic syndrome, and hematopoietic malignancies. Hematopoietic stem cell
transplantation (HSCT) provides an opportunity in which to study telomere dynamics in a …