[HTML][HTML] Treatment of metastatic melanoma with autologous CD4+ T cells against NY-ESO-1

NN Hunder, H Wallen, J Cao… - … England Journal of …, 2008 - Mass Medical Soc
NN Hunder, H Wallen, J Cao, DW Hendricks, JZ Reilly, R Rodmyre, A Jungbluth, S Gnjatic…
New England Journal of Medicine, 2008Mass Medical Soc
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell
clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these
cells into a patient with refractory metastatic melanoma who had not undergone any
previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells
mediated a durable clinical remission and led to endogenous responses against melanoma
antigens other than NY-ESO-1.
We developed an in vitro method for isolating and expanding autologous CD4+ T-cell clones with specificity for the melanoma-associated antigen NY-ESO-1. We infused these cells into a patient with refractory metastatic melanoma who had not undergone any previous conditioning or cytokine treatment. We show that the transferred CD4+ T cells mediated a durable clinical remission and led to endogenous responses against melanoma antigens other than NY-ESO-1.
The New England Journal Of Medicine