[HTML][HTML] Mitochondrial dynamics: regulatory mechanisms and emerging role in renal pathophysiology

M Zhan, C Brooks, F Liu, L Sun, Z Dong - Kidney international, 2013 - Elsevier
M Zhan, C Brooks, F Liu, L Sun, Z Dong
Kidney international, 2013Elsevier
Mitochondria are a class of dynamic organelles that constantly undergo fission and fusion.
Mitochondrial dynamics is governed by a complex molecular machinery and finely tuned by
regulatory proteins. During cell injury or stress, the dynamics is shifted to fission, resulting in
mitochondrial fragmentation, which contributes to mitochondrial damage and consequent
cell injury and death. Emerging evidence has suggested a role of mitochondrial
fragmentation in the pathogenesis of renal diseases including acute kidney injury and …
Mitochondria are a class of dynamic organelles that constantly undergo fission and fusion. Mitochondrial dynamics is governed by a complex molecular machinery and finely tuned by regulatory proteins. During cell injury or stress, the dynamics is shifted to fission, resulting in mitochondrial fragmentation, which contributes to mitochondrial damage and consequent cell injury and death. Emerging evidence has suggested a role of mitochondrial fragmentation in the pathogenesis of renal diseases including acute kidney injury and diabetic nephropathy. A better understanding of the regulation of mitochondrial dynamics and its pathogenic changes may unveil novel therapeutic strategies.
Elsevier