Effects of smoking intervention and the use of an inhaled anticholinergic bronchodilator on the rate of decline of FEV1: the Lung Health Study

NR Anthonisen, JE Connett, JP Kiley, MD Altose… - Jama, 1994 - jamanetwork.com
Objective.—To determine whether a program incorporating smoking intervention and use of
an inhaled bronchodilator can slow the rate of decline in forced expiratory volume in 1
second (FEV 1) in smokers aged 35 to 60 years who have mild obstructive pulmonary
disease. Design.—Randomized clinical trial. Participants randomized with equal probability
to one of the following groups:(1) smoking intervention plus bronchodilator,(2) smoking
intervention plus placebo, or (3) no intervention. Setting.—Ten clinical centers in the United …