[HTML][HTML] Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family
RM Pitti, SA Marsters, S Ruppert, CJ Donahue… - Journal of Biological …, 1996 - ASBMB
Cytokines in the tumor necrosis factor (TNF) family regulate development and function of the
immune system. We have isolated a new member of this family, designated Apo-2 ligand
(Apo-2L), via an expressed sequence tag. Apo-2L is a 281-amino acid protein, related most
closely to Fas/Apo-1 ligand. Transfected Apo-2L is expressed at the cell surface with its C
terminus exposed, indicating a type II transmembrane protein topology. Like Fas/Apo-1
ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) …
immune system. We have isolated a new member of this family, designated Apo-2 ligand
(Apo-2L), via an expressed sequence tag. Apo-2L is a 281-amino acid protein, related most
closely to Fas/Apo-1 ligand. Transfected Apo-2L is expressed at the cell surface with its C
terminus exposed, indicating a type II transmembrane protein topology. Like Fas/Apo-1
ligand and TNF, the C-terminal extracellular region of Apo-2L (amino acids 114-281) …